There are two types of dermal drug delivery systems: chemical and physical. The physical methods for improving drug transdermal permeability include: 1. Iontophoresis; 2. Electroporation; 3. Ultrasound biointroduction; 4. Micro-manufacturing microneedle technology; 5. Needle-free jet delivery; Transdermal administration; 7. Transdermal administration promoted by heat energy.

According to the aerodynamics principle, "molecular atomizer" does not use needles when injecting drugs, and the low pressure mediated by helium allows liquid drugs to eject molecular-level atomized particles at 2.5 times the impact of supersonic speed, and instantly enter the skin organize. Needle-free administration allows for faster absorption of drugs and skin care products, as well as more uniform diffusion absorption; no needles, no pain, no trauma, and no infection.

It is a very new technology to deliver the medicines we need to where we need them without breaking the skin. During operation, the atomized gun barrel does not touch the skin, but keeps a certain distance so that the drug will have an acceleration after leaving the gun barrel, and the atomized effective substance will be sprayed into the skin without pain or damage to the skin. When the pressure difference between the inside and outside of the nozzle is greater than one atmosphere, the molecular atomizer can generate supersonic flow in the atmosphere, according to aerodynamic theory. Furthermore, particles in a supersonic flow can be accelerated from static to extremely high speed only a few centimeters away, according to the theory of two-phase flow. Based on the above two principles, the only need is to use helium gas and a very low pressure by changing the design of the nozzle curve and the operation method, and it can accelerate the microparticles to a very high speed with the gas while causing no harm to the cells and producing little noise.