Hydrogen for colitis Nov 17,2022.
Enteritis refers to inflammatory lesions of the colon caused by various reasons. It can be caused by organisms such as bacteria, fungi, viruses, parasites, and protozoa, and can also be caused by allergic reactions and physical and chemical factors. According to different causes, it can be divided into specific inflammatory lesions and non-specific inflammatory lesions. The former refers to infectious colitis, Ischemic colitis and pseudomembranous colitis, the latter including ulcerative colitis and colonic Crohn's disease. The main clinical manifestations are diarrhea, abdominal pain, mucus and bloody stools, tenesmus, or even constipation, inability to defecate within a few days; often accompanied by weight loss and fatigue, etc., often recurrent. The incidence of ulcerative colitis in my country is gradually increasing, the course of the disease is lengthy, and there is a risk of concurrent colon cancer, so it has received more and more attention.

The etiology of colitis is multifactorial, but is generally related to excessive inflammation and oxidative stress damage. At present, there is no ideal drug and method for curing colitis, and the drugs used to treat this disease often have serious toxic side effects. In order to study ulcerative colitis, dextran sodium sulfate (DSS) is often used to induce colitis in experimental animals. By adjusting the DSS concentration or administration cycle, it is easy to induce acute, chronic or recurrent colitis. Hydrogen is thought to have anti-inflammatory and antioxidant properties, which may make it a new drug for treating colitis.

In this study, a mouse model of acute colitis was induced by administering dextran sodium sulfate (DSS) in drinking water for 7 days. Mice were divided into 5 groups (n=6) as normal, colitis, H2-treated colitis, sulfapyridine-treated colitis, and H2 + sulfapyridine-treated colitis. Treatment groups From day 3 to day 10, mice were given H2, sulfapyridine, or both. Hydrogen-releasing tablets were dissolved in water to prepare hydrogen-rich water (HRW). Animals were allowed to eat and drink freely, and 200 microliters of hydrogen water was gavaged. Disease activity index (DAI), histological changes, markers of inflammation and oxidative stress were assessed separately.

It was found that both the hydrogen water group and sulfasalazine significantly improved body weight, DAI, mucosal damage, crypt loss, and spleen weight compared with the disease control group. Both treatments significantly reduced inflammation (high-sensitivity C-reactive protein) and restored redox balance (total thiols, superoxide dismutase, catalase activity). There is a trend that combination therapy is more effective than hydrogen water or sulfasalazine alone. Additionally, hydrogen water groups tend to be as effective as, and often more effective than, sulfasalazine. The results showed that hydrogen water had a therapeutic effect on DSS-induced colitis in mice.

This research paper was recently published in EXCLI J by LeBaron TW, a well-known hydrogen medicine scholar in the United States.
LeBaron TW, Asgharzadeh F, Khazei M, Kura B, Tarnava A, Slezak J. Molecular hydrogen is comparable to sulfasalazine as a treatment for DSS-induced colitis in mice. EXCLI J. 2021 Jun 29;20:1106-1117.

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