The effect of hydrogen on human immune cells
Dec 26,2022.
This study started from the phenomenon of hydrogen deficiency in premature pregnant women, studied the relationship between hydrogen and premature birth, and observed the corresponding observation of hydrogen in blood T cells of healthy people, and found that hydrogen has a certain effect on the differentiation and proliferation of T cells. The study not only suggests that measuring hydrogen levels in the body may predict preterm birth, but also has implications for noninvasive testing of other diseases and health conditions. More importantly, this study found that hydrogen has an effect on the immune cells of healthy people, which means that hydrogen may have a physiological immune function regulation effect. Unfortunately, the research is still not comprehensive enough, and the observation time is not long enough. This study suggests that research on the function of immune cells in healthy people may be an important direction for the medical effects of hydrogen.
Hydrogen has received increasing attention for its role in a variety of diseases. However, the molecular mechanism by which a small amount of hydrogen produces the remarkable effect remains unclear. There is currently no knowledge about the role of hydrogen in the etiology of pregnancy disorders or the direct effects of hydrogen on immune cells in humans. T cells in particular play a crucial role in pregnancy maintenance due to maternal immunity. This article explores the effect of hydrogen on T cells and its relationship to preterm birth.
Main methods: Determination of the concentration of hydrogen in the exhaled breath of pregnant women, and the correlation analysis with the concentration of cytokines in maternal blood and umbilical cord blood. T cells were collected from healthy donors, added hydrogen, and detected their differentiation, proliferation and energy metabolism. Mice were administered hydrogen gas and cytokine expression compared.
Maternal hydrogen production was significantly lower in pregnant women with preterm birth in this prospective observational study, suggesting its potential as a predictive biomarker for preterm birth. We found that hydrogen gas is clearly associated with several maternal cytokines and acts as an immunomodulator by exerting mitochondrial function in human T cells. In addition, intraoral administration of hydrogen gas modulated inflammatory responses and reduced T cell activation-induced preterm birth, further supporting the idea that hydrogen gas may promote pregnancy prolongation through its immunomodulatory effects.
Implications for the study: Measuring maternal hydrogen production may be a potential clinical tool in the management of preterm birth, and hydrogen may have a positive effect on pregnancy maintenance.
Research highlights:
Preterm women have significantly lower levels of hydrogen production in their bodies.
Hydrogen has the potential to modulate cytokine production by T cells.
Hydrogen may increase mitochondrial function by increasing mitochondrial ROS.
Administration of hydrogen to pregnant women may be beneficial in promoting pregnancy maintenance.
Aoki C, Imai K, Mizutani T, Sugiyama D, Miki R, Koya Y, Kobayashi T, Ushida T, Iitani Y, Nakamura N, Owaki T, Nishikawa H, Toyokuni S, Kajiyama H, Kotani T. Molecular hydrogen has a positive impact on pregnancy maintenance through enhancement of mitochondrial function and immunomodulatory effects on T cells. Life Sci. 2022 Sep 14:
The above content is excerpted from Sun Xuejun's "Hydrogen Thinking Language", which is limited to knowledge popularization and does not represent the promotion of the company's products.
